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-synuclein, that's a most important component of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, and that is an E3 ubiquitin ligase and causes endoplasmic reticulum (ER) tension, recommend that dysfunction on the intracellular proteinase programs, for instance ubiquitin-proteasome process or lysosomal procedure, which gets rid of needl… Read More